NASDAQ Framework: Intellia Therapeutics Inc.

Gene editing company developing CRISPR therapeutics 1.

Intellia Therapeutics, Inc. is a leading clinical-stage biotechnology company focused on developing novel, potentially curative therapeutics leveraging CRISPR-based technologies 2. The company's in vivo programs use intravenously administered CRISPR as the therapy, enabling highly precise editing of disease-causing genes directly within specific target tissues 3. Intellia's ex vivo programs use CRISPR to engineer human cells outside the body for the treatment of cancer and autoimmune diseases 4. The company has formed collaborations with several companies, including Regeneron and Novartis, to advance its pipeline 5. Founded in 2014, Intellia continues to expand its CRISPR-based platform with novel editing and delivery technologies 6.

2: Intellia Therapeutics, Inc. is an American clinical-stage biotechnology company focused on developing novel, potentially curative therapeutics leveraging CRISPR-based technologies. The company's in vivo programs use intravenously administered CRISPR as the therapy, in which the company's proprietary delivery technology enables highly precise editing of disease-causing genes directly within specific target tissues. Intellia's ex vivo programs use CRISPR to create the therapy by using engineered human cells to treat cancer and autoimmune diseases.[2] View Source3: Intellia Therapeutics, Inc. is an American clinical-stage biotechnology company focused on developing novel, potentially curative therapeutics leveraging CRISPR-based technologies. The company's in vivo programs use intravenously administered CRISPR as the therapy, in which the company's proprietary delivery technology enables highly precise editing of disease-causing genes directly within specific target tissues. Intellia's ex vivo programs use CRISPR to create the therapy by using engineered human cells to treat cancer and autoimmune diseases.[2] View Source4: Intellia Therapeutics, Inc. (NASDAQ:NTLA) is a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies. The company’s in vivo programs use CRISPR to enable precise editing of disease-causing genes directly inside the human body. Intellia’s ex vivo programs use CRISPR to engineer human cells outside the body for the treatment of cancer and autoimmune diseases. Intellia’s deep scientific, technical and clinical development experience, along with its people, is helping set the standard for a new class of medicine. To harness the full potential of gene editing, Intellia continues to expand the capabilities of its CRISPR-based platform with novel editing and delivery technologies. Learn more at intelliatx.com and follow us @intelliatx. View Source5: Intellia Earnings: Novel Gene Editing Pipeline Advances; Shares Attractive for Long-Term Investors Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia's Gene Editing Pipeline Looks Promising for Long-Term Investors With High Risk Tolerance Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia Earnings: Early-Stage Gene Editing Pipeline Makes Progress; Shares Very Undervalued Intellia Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 4 months ago Daily – Vickers Top Buyers & Sellers for 01/08/2024 The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions. Argus• 6 months ago View Source6: Intellia Therapeutics was founded in November 2014 to develop biopharmaceuticals using CRISPR.[7][8] View Source

NO

Intellia Therapeutics Inc. is not currently led by its founders. The founding CEO was Nessan Bermingham, and the founding CSO was John Leonard 7. John Leonard is now the President and Chief Executive Officer 8, but there is no indication that other founders are heavily involved in the current leadership.

7: It was backed by Atlas Venture and Novartis; the founding CEO was Nessan Bermingham from Atlas and the founding CSO was John Leonard, formerly CSO of AbbVie. The academic scientists involved in the founding included Rodolphe Barrangou, Rachel Haurwitz, Luciano Marraffini, Erik Sontheimer, and Derrick Rossi.[7][9] The intellectual property around CRISPR was contested from the beginning; Intellia in-licensed patents from Caribou Biosciences, which had licensed patents from University of California invented by Jennifer Doudna.[10][11][12] View Source8: CAMBRIDGE, Mass., June 26, 2024 (GLOBE NEWSWIRE) -- Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies, today announced the appointment of Edward Dulac as Executive Vice President, Chief Financial Officer (CFO), and Treasurer, effective July 22, 2024. Mr. Dulac will succeed Glenn Goddard who will step down from his role effective June 30, 2024. View Source

MEDIUM RISK

Intellia Therapeutics Inc. is a clinical-stage biotechnology company focused on developing CRISPR-based therapeutics, which inherently involves high research and development costs. While the company has shown promising clinical data and formed significant collaborations with companies like Regeneron and Novartis 9 10, it also faces substantial risks. These include the potential for unsuccessful product development, challenges in advancing CRISPR-based therapies into late-stage clinical development, and maintaining its intellectual property position 11. Additionally, the company has experienced executive transitions and insider sales 12 13, which could indicate internal challenges. However, its ongoing clinical trials and strategic partnerships provide a balanced outlook, placing it at medium risk.

9: Intellia Earnings: Novel Gene Editing Pipeline Advances; Shares Attractive for Long-Term Investors Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia's Gene Editing Pipeline Looks Promising for Long-Term Investors With High Risk Tolerance Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia Earnings: Early-Stage Gene Editing Pipeline Makes Progress; Shares Very Undervalued Intellia Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 4 months ago Daily – Vickers Top Buyers & Sellers for 01/08/2024 The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions. Argus• 6 months ago View Source10: Intellia Therapeutics, Inc. (NASDAQ:NTLA) is a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies. The company’s in vivo programs use CRISPR to enable precise editing of disease-causing genes directly inside the human body. Intellia’s ex vivo programs use CRISPR to engineer human cells outside the body for the treatment of cancer and autoimmune diseases. Intellia’s deep scientific, technical and clinical development experience, along with its people, is helping set the standard for a new class of medicine. To harness the full potential of gene editing, Intellia continues to expand the capabilities of its CRISPR-based platform with novel editing and delivery technologies. Learn more at intelliatx.com and follow us @intelliatx. View Source11: Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: the risk that any one or more of our product candidates, including those that are co-developed, will not be successfully developed and commercialized, including risks related to the authorization, initiation and conduct of studies and other development requirements for our product candidates such as advancing CRISPR-based therapies into late-stage clinical development; the risk that the results of preclinical studies or clinical studies will not be predictive of future results in connection with future studies; risks related to our relationship with third parties, including our licensors, licensees and other collaborators; and risks related to our, and our licensors’, ability to protect and maintain our intellectual property position. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause Intellia’s actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in Intellia’s most recent annual report on Form 10-K and quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in Intellia’s other filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Intellia undertakes no duty to update this information unless required by law. View Source12: Almost all investors and traders prefer to invest in shares controlled by the management of a corporation as a management company will be more likely to run the business itself and to never conduct things against the management’s desires and will always try to do what is best for their shareholders. Currently, 1.99 percent of Intellia Therapeutics Inc shares are owned by insiders, and 91.32 percent are held by financial institutions. Clark Eliana, the EVP, Chief Technical Officer at Intellia Therapeutics Inc (NTLA) has sold 405 shares of firm on Jul 01 ’24 at a price of $22.93 against the total amount of $9287.0. In another inside trade, Verwiel Frank, Director of Intellia Therapeutics Inc (NASDAQ:NTLA) sold 1,505 shares of the firm on Jun 17 ’24 for a total worth of $37625.0 at a price of $25.00. An inside trade which took place on Mar 04 ’24, EVP, General Counsel of Intellia Therapeutics Inc BASTA JAMES sold 2,297 shares of firm against total price of $75778.0 at the cost of $32.99 per share. View Source13: CAMBRIDGE, Mass., June 26, 2024 (GLOBE NEWSWIRE) -- Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies, today announced the appointment of Edward Dulac as Executive Vice President, Chief Financial Officer (CFO), and Treasurer, effective July 22, 2024. Mr. Dulac will succeed Glenn Goddard who will step down from his role effective June 30, 2024. View Source

UNKNOWN

There is no specific evidence provided that confirms whether Intellia Therapeutics Inc. is launching any new product offerings at this time. The available information focuses on their ongoing clinical trials and collaborations but does not mention any new product launches 14 15 16 17.

14: ^ a b c d e f "2022 Annual Report (Form 10-K)". U.S. Securities and Exchange Commission. 23 February 2023. ^ "About Intellia". Intellia Corporate Website. Retrieved 15 November 2022. ^ "NTLA-2001 Trial Overview". Clinicaltrials.gov. Retrieved 15 November 2022. ^ "NTLA-2002 Trial Overview". Clinicaltrials.gov. Retrieved 15 November 2022. ^ "Intellia Therapeutics Presents New Data on Expanded Cell Engineering Capabilities Utilizing Base Editors". Globe Newswire. 25 March 2021. ^ "Intellia Therapeutics Announces Acquisition of Rewrite Therapeutics". Globe Newswire. 23 February 2022. ^ a b Carroll, John (18 November 2014). "Novartis joins Atlas in launching a CRISPR Cas biotech with a $15M bankroll". FierceBiotech. Framingham, Massachusetts: Questex. Archived from the original on 6 May 2016. Retrieved 10 February 2020. ^ Rockoff, Jonathan (28 June 2015). "Why Gene Editing Has Scientists Excited". Wall Street Journal. Dow Jones Products. Retrieved 10 February 2020. ^ "Intellia Therapeutics Announces Dr. Jennifer Doudna And Dr. Derrick Rossi To Join Company". BioSpace. 22 April 2015. Archived from the original on 27 May 2021. Retrieved 27 May 2021. ^ a b Lash, Alex (7 January 2015). "CART + CRISPR = 1st-Of-Its-Kind Biotech Deal From Novartis, Intellia". Xconomy. Boston, Massachusetts: Brian Caine. Retrieved 10 February 2020. Note - the second page of the article appears here. ^ Lash, Alex (18 November 2014). "With Atlas Cash and Berkeley Tools, Intellia Joins the CRISPR Fray". Xconomy. Boston, Massachusetts. Retrieved 10 February 2020. Note - the article's second page appears here. ^ Isaacson, Walter (2021). The Code Breaker. Simon & Schuster. p. 213. ISBN 978-1-9821-1585-2. ^ Staff (14 January 2016). "Intellia Therapeutics Forms New Division eXtellia for Joint Programs with Novartis". BIO.IT World. Needham, Massachusetts: CHI. Retrieved 10 February 2020. ^ Carlook, Catherine (22 January 2016). "Exclusive: Fast-growing gene-editing biotech expanding near Kendall Square". Boston Business Journal. American City Business Journals. Retrieved 10 February 2020. ^ Lash, Alex (1 September 2015). "CRISPR Cash: Intellia The Latest Gene-Editing Firm To Nab Big Money". Xconomy. Boston, Massachusetts. Retrieved 10 February 2020. ^ a b Stendahl, Max (8 March 2017). "Intellia R&D head says new gene-editing data shows path to human trials". Boston Business Journal. American City Business Journals. ^ Le Page, Michael (2 October 2017). "We're nearly ready to use CRISPR to target far more diseases". New Scientist. Retrieved 10 February 2020. ^ "Regeneron, Intellia Partner to Develop CRISPR/Cas Therapeutics". Genetic Engineering & Biotechnology News. New Rochelle, New York: Mary Ann Liebert. 11 April 2016. Retrieved 10 February 2020. ^ Taylor, Nick Paul (6 May 2016). "Intellia set to invest millions in CRISPR informatics platform after nailing upsized IPO". FierceBiotech. Framingham, Massachusetts: Questex. Retrieved 10 February 2020. ^ "Intellia Therapeutics Names John Leonard, M.D., President and Chief Executive Officer" (Press release). Intellia Therapeutics. 18 December 2017. Retrieved 10 February 2020.[self-published source] ^ "Intellia Therapeutics Names Glenn Goddard as New Chief Financial Officer" (Press release). Intellia Therapeutics. 29 October 2018. Retrieved 18 March 2020 – via GlobeNewswire News Room. ^ "Intellia Therapeutics Names Glenn Goddard as New Chief Financial Officer". Biotech Finances (in French). 2 November 2018. Retrieved 18 March 2020. ^ Ledford, Heidi (15 October 2020). "Pioneers of revolutionary CRISPR gene editing win chemistry Nobel". Nature. 586 (7829): 346–347. Bibcode:2020Natur.586..346L. doi:10.1038/d41586-020-02765-9. PMID 33028993. S2CID 222213702. ^ Gillmore, Julian (5 August 2021). "CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis". New England Journal of Medicine. 385 (6): 493–502. doi:10.1056/NEJMoa2107454. PMID 34215024. S2CID 235722446. ^ Armstrong, Annalee (12 November 2022). "Intellia is ready to talk 'functional cure' for HAE with interim data in hand for 2nd CRISPR candidate". Fierce Biotech. Retrieved 15 November 2022. ^ "Intellia Therapeutics Highlights its Three-Year Strategic Priorities and Anticipated 2024 Key Milestones". January 4, 2024. Retrieved February 4, 2024. ^ Gormley, Brian (November 18, 2014). "Intellia Therapeutics Raises $15M Series A for Gene Editing Therapies". Wall Street Journal. Dow Jones. ^ Newsham, Jack (September 1, 2015). "Intellia raises $70 million for gene-editing treatments". Boston Globe. ^ a b "Form 10-K for the Fiscal Year Ended December 31, 2016". Intellia via SEC Edgar. ^ Beckerman, Josh (May 6, 2016). "Stock in Biotech Company Intellia Rises 23% After Upsized IPO". Wall Street Journal. Dow Jones. View Source15: Intellia Earnings: Novel Gene Editing Pipeline Advances; Shares Attractive for Long-Term Investors Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia's Gene Editing Pipeline Looks Promising for Long-Term Investors With High Risk Tolerance Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia Earnings: Early-Stage Gene Editing Pipeline Makes Progress; Shares Very Undervalued Intellia Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 4 months ago Daily – Vickers Top Buyers & Sellers for 01/08/2024 The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions. Argus• 6 months ago View Source16: Intellia Therapeutics, Inc., a genome editing company, focuses on the development of curative therapeutics. The company's in vivo programs include NTLA-2001, which is in Phase 1 clinical trial for the treatment of transthyretin amyloidosis; NTLA-2002 for the treatment of hereditary angioedema; and NTLA-3001 for alpha-1 antitrypsin deficiency associated lung disease. It also focusses on programs comprising hemophilia A and hemophilia B; and research of proprietary programs focused on developing engineered cell therapies to treat various cancers and autoimmune diseases. In addition, the company offers tools comprising of Clustered, Regularly Interspaced Short Palindromic Repeats/CRISPR associated 9 (CRISPR/Cas9) system. It has license and collaboration agreement with Regeneron Pharmaceuticals, Inc. to co-develop potential products for the treatment of hemophilia A and hemophilia B; AvenCell Therapeutics, Inc. to develop allogeneic universal CAR-T cell therapies, and co-develop and co-commercialize allogeneic universal CAR-T cell products for an immuno-oncology indication; SparingVision SAS to develop novel genomic medicines utilizing CRISPR/Cas9 technology for the treatment of ocular diseases; Kyverna Therapeutics, Inc. for the development of an allogeneic CD19 CAR-T cell therapy for the treatment of a variety of B cell-mediated autoimmune diseases; and ONK Therapeutics, Ltd. for the development of engineered NK cell therapies to cure patients with cancer. Intellia Therapeutics, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts. View Source17: Intellia has two in vivo programs in ongoing clinical trials. NTLA-2001 is an investigational CRISPR therapy candidate for the treatment for ATTR amyloidosis currently in Phase 1 studies.[3] NTLA-2002 is an investigational CRISPR therapy candidate for the treatment of hereditary angioedema (HAE) currently in Phase 1 / 2 studies.[4] View Source

Intellia Therapeutics Inc.'s product roadmap for 2024 through to 2026 focuses on advancing its CRISPR-based therapeutic pipeline, particularly in vivo and ex vivo programs targeting genetically defined diseases. The company is progressing its clinical trials for NTLA-2001, aimed at treating transthyretin amyloidosis, and NTLA-2002, for hereditary angioedema, both of which are in early-stage clinical development 18. Additionally, Intellia is expanding its capabilities with novel editing and delivery technologies and has formed strategic collaborations with companies like Regeneron and Novartis to co-develop potential products for various indications, including hemophilia and cancer 19 20. The company aims to leverage these partnerships and its proprietary non-viral gene knockout platform to address diseases with high unmet medical needs 21.

18: Intellia has two in vivo programs in ongoing clinical trials. NTLA-2001 is an investigational CRISPR therapy candidate for the treatment for ATTR amyloidosis currently in Phase 1 studies.[3] NTLA-2002 is an investigational CRISPR therapy candidate for the treatment of hereditary angioedema (HAE) currently in Phase 1 / 2 studies.[4] View Source19: Intellia Therapeutics, Inc., a genome editing company, focuses on the development of curative therapeutics. The company's in vivo programs include NTLA-2001, which is in Phase 1 clinical trial for the treatment of transthyretin amyloidosis; NTLA-2002 for the treatment of hereditary angioedema; and NTLA-3001 for alpha-1 antitrypsin deficiency associated lung disease. It also focusses on programs comprising hemophilia A and hemophilia B; and research of proprietary programs focused on developing engineered cell therapies to treat various cancers and autoimmune diseases. In addition, the company offers tools comprising of Clustered, Regularly Interspaced Short Palindromic Repeats/CRISPR associated 9 (CRISPR/Cas9) system. It has license and collaboration agreement with Regeneron Pharmaceuticals, Inc. to co-develop potential products for the treatment of hemophilia A and hemophilia B; AvenCell Therapeutics, Inc. to develop allogeneic universal CAR-T cell therapies, and co-develop and co-commercialize allogeneic universal CAR-T cell products for an immuno-oncology indication; SparingVision SAS to develop novel genomic medicines utilizing CRISPR/Cas9 technology for the treatment of ocular diseases; Kyverna Therapeutics, Inc. for the development of an allogeneic CD19 CAR-T cell therapy for the treatment of a variety of B cell-mediated autoimmune diseases; and ONK Therapeutics, Ltd. for the development of engineered NK cell therapies to cure patients with cancer. Intellia Therapeutics, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts. View Source20: In April 2017 Intellia entered into a partnership with Regeneron Pharmaceuticals under which Regeneron gained the exclusive right to use Intellia's CRISPR platform on up to 10 drug targets, of which up to five could be outside of the liver, and the companies agreed to co-develop other targets. Regeneron paid $75 million upfront, as well as milestones and royalties.[18] The company said it planned to put $10 million of the funds into its bioinformatics program, to help it evaluate targets.[19] View Source21: Intellia's proprietary non-viral gene knock out platform deploys lipid nanoparticles to deliver to the liver a two-part genome editing system: guide RNA specific to the disease-causing gene and messenger RNA that encodes the Cas9 enzyme, which carries out the precision editing. Intellia also has a number of research programs for in vivo and ex vivo therapeutic candidates with potential applications in diseases including cancer, alpha-1 antitrypsin deficiency, and hemophilia. The company is also working on a variety of additional gene editing technologies including base editing and DNA writing.[5][6] View Source

Sources

1: Intellia Earnings: Novel Gene Editing Pipeline Advances; Shares Attractive for Long-Term Investors Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia's Gene Editing Pipeline Looks Promising for Long-Term Investors With High Risk Tolerance Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia Earnings: Early-Stage Gene Editing Pipeline Makes Progress; Shares Very Undervalued Intellia Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 4 months ago Daily – Vickers Top Buyers & Sellers for 01/08/2024 The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions. Argus• 6 months ago View Source2: Intellia Therapeutics, Inc. is an American clinical-stage biotechnology company focused on developing novel, potentially curative therapeutics leveraging CRISPR-based technologies. The company's in vivo programs use intravenously administered CRISPR as the therapy, in which the company's proprietary delivery technology enables highly precise editing of disease-causing genes directly within specific target tissues. Intellia's ex vivo programs use CRISPR to create the therapy by using engineered human cells to treat cancer and autoimmune diseases.[2] View Source3: Intellia Therapeutics, Inc. is an American clinical-stage biotechnology company focused on developing novel, potentially curative therapeutics leveraging CRISPR-based technologies. The company's in vivo programs use intravenously administered CRISPR as the therapy, in which the company's proprietary delivery technology enables highly precise editing of disease-causing genes directly within specific target tissues. Intellia's ex vivo programs use CRISPR to create the therapy by using engineered human cells to treat cancer and autoimmune diseases.[2] View Source4: Intellia Therapeutics, Inc. (NASDAQ:NTLA) is a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies. The company’s in vivo programs use CRISPR to enable precise editing of disease-causing genes directly inside the human body. Intellia’s ex vivo programs use CRISPR to engineer human cells outside the body for the treatment of cancer and autoimmune diseases. Intellia’s deep scientific, technical and clinical development experience, along with its people, is helping set the standard for a new class of medicine. To harness the full potential of gene editing, Intellia continues to expand the capabilities of its CRISPR-based platform with novel editing and delivery technologies. Learn more at intelliatx.com and follow us @intelliatx. View Source5: Intellia Earnings: Novel Gene Editing Pipeline Advances; Shares Attractive for Long-Term Investors Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia's Gene Editing Pipeline Looks Promising for Long-Term Investors With High Risk Tolerance Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia Earnings: Early-Stage Gene Editing Pipeline Makes Progress; Shares Very Undervalued Intellia Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 4 months ago Daily – Vickers Top Buyers & Sellers for 01/08/2024 The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions. Argus• 6 months ago View Source6: Intellia Therapeutics was founded in November 2014 to develop biopharmaceuticals using CRISPR.[7][8] View Source7: It was backed by Atlas Venture and Novartis; the founding CEO was Nessan Bermingham from Atlas and the founding CSO was John Leonard, formerly CSO of AbbVie. The academic scientists involved in the founding included Rodolphe Barrangou, Rachel Haurwitz, Luciano Marraffini, Erik Sontheimer, and Derrick Rossi.[7][9] The intellectual property around CRISPR was contested from the beginning; Intellia in-licensed patents from Caribou Biosciences, which had licensed patents from University of California invented by Jennifer Doudna.[10][11][12] View Source8: CAMBRIDGE, Mass., June 26, 2024 (GLOBE NEWSWIRE) -- Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies, today announced the appointment of Edward Dulac as Executive Vice President, Chief Financial Officer (CFO), and Treasurer, effective July 22, 2024. Mr. Dulac will succeed Glenn Goddard who will step down from his role effective June 30, 2024. View Source9: Intellia Earnings: Novel Gene Editing Pipeline Advances; Shares Attractive for Long-Term Investors Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia's Gene Editing Pipeline Looks Promising for Long-Term Investors With High Risk Tolerance Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia Earnings: Early-Stage Gene Editing Pipeline Makes Progress; Shares Very Undervalued Intellia Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 4 months ago Daily – Vickers Top Buyers & Sellers for 01/08/2024 The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions. Argus• 6 months ago View Source10: Intellia Therapeutics, Inc. (NASDAQ:NTLA) is a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies. The company’s in vivo programs use CRISPR to enable precise editing of disease-causing genes directly inside the human body. Intellia’s ex vivo programs use CRISPR to engineer human cells outside the body for the treatment of cancer and autoimmune diseases. Intellia’s deep scientific, technical and clinical development experience, along with its people, is helping set the standard for a new class of medicine. To harness the full potential of gene editing, Intellia continues to expand the capabilities of its CRISPR-based platform with novel editing and delivery technologies. Learn more at intelliatx.com and follow us @intelliatx. View Source11: Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: the risk that any one or more of our product candidates, including those that are co-developed, will not be successfully developed and commercialized, including risks related to the authorization, initiation and conduct of studies and other development requirements for our product candidates such as advancing CRISPR-based therapies into late-stage clinical development; the risk that the results of preclinical studies or clinical studies will not be predictive of future results in connection with future studies; risks related to our relationship with third parties, including our licensors, licensees and other collaborators; and risks related to our, and our licensors’, ability to protect and maintain our intellectual property position. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause Intellia’s actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in Intellia’s most recent annual report on Form 10-K and quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in Intellia’s other filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Intellia undertakes no duty to update this information unless required by law. View Source12: Almost all investors and traders prefer to invest in shares controlled by the management of a corporation as a management company will be more likely to run the business itself and to never conduct things against the management’s desires and will always try to do what is best for their shareholders. Currently, 1.99 percent of Intellia Therapeutics Inc shares are owned by insiders, and 91.32 percent are held by financial institutions. Clark Eliana, the EVP, Chief Technical Officer at Intellia Therapeutics Inc (NTLA) has sold 405 shares of firm on Jul 01 ’24 at a price of $22.93 against the total amount of $9287.0. In another inside trade, Verwiel Frank, Director of Intellia Therapeutics Inc (NASDAQ:NTLA) sold 1,505 shares of the firm on Jun 17 ’24 for a total worth of $37625.0 at a price of $25.00. An inside trade which took place on Mar 04 ’24, EVP, General Counsel of Intellia Therapeutics Inc BASTA JAMES sold 2,297 shares of firm against total price of $75778.0 at the cost of $32.99 per share. View Source13: CAMBRIDGE, Mass., June 26, 2024 (GLOBE NEWSWIRE) -- Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies, today announced the appointment of Edward Dulac as Executive Vice President, Chief Financial Officer (CFO), and Treasurer, effective July 22, 2024. Mr. Dulac will succeed Glenn Goddard who will step down from his role effective June 30, 2024. View Source14: ^ a b c d e f "2022 Annual Report (Form 10-K)". U.S. Securities and Exchange Commission. 23 February 2023. ^ "About Intellia". Intellia Corporate Website. Retrieved 15 November 2022. ^ "NTLA-2001 Trial Overview". Clinicaltrials.gov. Retrieved 15 November 2022. ^ "NTLA-2002 Trial Overview". Clinicaltrials.gov. Retrieved 15 November 2022. ^ "Intellia Therapeutics Presents New Data on Expanded Cell Engineering Capabilities Utilizing Base Editors". Globe Newswire. 25 March 2021. ^ "Intellia Therapeutics Announces Acquisition of Rewrite Therapeutics". Globe Newswire. 23 February 2022. ^ a b Carroll, John (18 November 2014). "Novartis joins Atlas in launching a CRISPR Cas biotech with a $15M bankroll". FierceBiotech. Framingham, Massachusetts: Questex. Archived from the original on 6 May 2016. Retrieved 10 February 2020. ^ Rockoff, Jonathan (28 June 2015). "Why Gene Editing Has Scientists Excited". Wall Street Journal. Dow Jones Products. Retrieved 10 February 2020. ^ "Intellia Therapeutics Announces Dr. Jennifer Doudna And Dr. Derrick Rossi To Join Company". BioSpace. 22 April 2015. Archived from the original on 27 May 2021. Retrieved 27 May 2021. ^ a b Lash, Alex (7 January 2015). "CART + CRISPR = 1st-Of-Its-Kind Biotech Deal From Novartis, Intellia". Xconomy. Boston, Massachusetts: Brian Caine. Retrieved 10 February 2020. Note - the second page of the article appears here. ^ Lash, Alex (18 November 2014). "With Atlas Cash and Berkeley Tools, Intellia Joins the CRISPR Fray". Xconomy. Boston, Massachusetts. Retrieved 10 February 2020. Note - the article's second page appears here. ^ Isaacson, Walter (2021). The Code Breaker. Simon & Schuster. p. 213. ISBN 978-1-9821-1585-2. ^ Staff (14 January 2016). "Intellia Therapeutics Forms New Division eXtellia for Joint Programs with Novartis". BIO.IT World. Needham, Massachusetts: CHI. Retrieved 10 February 2020. ^ Carlook, Catherine (22 January 2016). "Exclusive: Fast-growing gene-editing biotech expanding near Kendall Square". Boston Business Journal. American City Business Journals. Retrieved 10 February 2020. ^ Lash, Alex (1 September 2015). "CRISPR Cash: Intellia The Latest Gene-Editing Firm To Nab Big Money". Xconomy. Boston, Massachusetts. Retrieved 10 February 2020. ^ a b Stendahl, Max (8 March 2017). "Intellia R&D head says new gene-editing data shows path to human trials". Boston Business Journal. American City Business Journals. ^ Le Page, Michael (2 October 2017). "We're nearly ready to use CRISPR to target far more diseases". New Scientist. Retrieved 10 February 2020. ^ "Regeneron, Intellia Partner to Develop CRISPR/Cas Therapeutics". Genetic Engineering & Biotechnology News. New Rochelle, New York: Mary Ann Liebert. 11 April 2016. Retrieved 10 February 2020. ^ Taylor, Nick Paul (6 May 2016). "Intellia set to invest millions in CRISPR informatics platform after nailing upsized IPO". FierceBiotech. Framingham, Massachusetts: Questex. Retrieved 10 February 2020. ^ "Intellia Therapeutics Names John Leonard, M.D., President and Chief Executive Officer" (Press release). Intellia Therapeutics. 18 December 2017. Retrieved 10 February 2020.[self-published source] ^ "Intellia Therapeutics Names Glenn Goddard as New Chief Financial Officer" (Press release). Intellia Therapeutics. 29 October 2018. Retrieved 18 March 2020 – via GlobeNewswire News Room. ^ "Intellia Therapeutics Names Glenn Goddard as New Chief Financial Officer". Biotech Finances (in French). 2 November 2018. Retrieved 18 March 2020. ^ Ledford, Heidi (15 October 2020). "Pioneers of revolutionary CRISPR gene editing win chemistry Nobel". Nature. 586 (7829): 346–347. Bibcode:2020Natur.586..346L. doi:10.1038/d41586-020-02765-9. PMID 33028993. S2CID 222213702. ^ Gillmore, Julian (5 August 2021). "CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis". New England Journal of Medicine. 385 (6): 493–502. doi:10.1056/NEJMoa2107454. PMID 34215024. S2CID 235722446. ^ Armstrong, Annalee (12 November 2022). "Intellia is ready to talk 'functional cure' for HAE with interim data in hand for 2nd CRISPR candidate". Fierce Biotech. Retrieved 15 November 2022. ^ "Intellia Therapeutics Highlights its Three-Year Strategic Priorities and Anticipated 2024 Key Milestones". January 4, 2024. Retrieved February 4, 2024. ^ Gormley, Brian (November 18, 2014). "Intellia Therapeutics Raises $15M Series A for Gene Editing Therapies". Wall Street Journal. Dow Jones. ^ Newsham, Jack (September 1, 2015). "Intellia raises $70 million for gene-editing treatments". Boston Globe. ^ a b "Form 10-K for the Fiscal Year Ended December 31, 2016". Intellia via SEC Edgar. ^ Beckerman, Josh (May 6, 2016). "Stock in Biotech Company Intellia Rises 23% After Upsized IPO". Wall Street Journal. Dow Jones. View Source15: Intellia Earnings: Novel Gene Editing Pipeline Advances; Shares Attractive for Long-Term Investors Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia's Gene Editing Pipeline Looks Promising for Long-Term Investors With High Risk Tolerance Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 2 months ago Intellia Earnings: Early-Stage Gene Editing Pipeline Makes Progress; Shares Very Undervalued Intellia Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. Intellia is focused on using this technology to treat genetically defined diseases. It’s evaluating multiple gene editing approaches using in vivo and ex vivo therapies to address diseases with high unmet medical needs, including ATTR amyloidosis, hereditary angioedema, sickle cell disease, and immuno-oncology. Intellia has formed collaborations with several companies to advance its pipeline, including narrow-moat Regeneron and wide-moat Novartis. Rating Price Target Morningstar• 4 months ago Daily – Vickers Top Buyers & Sellers for 01/08/2024 The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions. Argus• 6 months ago View Source16: Intellia Therapeutics, Inc., a genome editing company, focuses on the development of curative therapeutics. The company's in vivo programs include NTLA-2001, which is in Phase 1 clinical trial for the treatment of transthyretin amyloidosis; NTLA-2002 for the treatment of hereditary angioedema; and NTLA-3001 for alpha-1 antitrypsin deficiency associated lung disease. It also focusses on programs comprising hemophilia A and hemophilia B; and research of proprietary programs focused on developing engineered cell therapies to treat various cancers and autoimmune diseases. In addition, the company offers tools comprising of Clustered, Regularly Interspaced Short Palindromic Repeats/CRISPR associated 9 (CRISPR/Cas9) system. It has license and collaboration agreement with Regeneron Pharmaceuticals, Inc. to co-develop potential products for the treatment of hemophilia A and hemophilia B; AvenCell Therapeutics, Inc. to develop allogeneic universal CAR-T cell therapies, and co-develop and co-commercialize allogeneic universal CAR-T cell products for an immuno-oncology indication; SparingVision SAS to develop novel genomic medicines utilizing CRISPR/Cas9 technology for the treatment of ocular diseases; Kyverna Therapeutics, Inc. for the development of an allogeneic CD19 CAR-T cell therapy for the treatment of a variety of B cell-mediated autoimmune diseases; and ONK Therapeutics, Ltd. for the development of engineered NK cell therapies to cure patients with cancer. Intellia Therapeutics, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts. View Source17: Intellia has two in vivo programs in ongoing clinical trials. NTLA-2001 is an investigational CRISPR therapy candidate for the treatment for ATTR amyloidosis currently in Phase 1 studies.[3] NTLA-2002 is an investigational CRISPR therapy candidate for the treatment of hereditary angioedema (HAE) currently in Phase 1 / 2 studies.[4] View Source18: Intellia has two in vivo programs in ongoing clinical trials. NTLA-2001 is an investigational CRISPR therapy candidate for the treatment for ATTR amyloidosis currently in Phase 1 studies.[3] NTLA-2002 is an investigational CRISPR therapy candidate for the treatment of hereditary angioedema (HAE) currently in Phase 1 / 2 studies.[4] View Source19: Intellia Therapeutics, Inc., a genome editing company, focuses on the development of curative therapeutics. The company's in vivo programs include NTLA-2001, which is in Phase 1 clinical trial for the treatment of transthyretin amyloidosis; NTLA-2002 for the treatment of hereditary angioedema; and NTLA-3001 for alpha-1 antitrypsin deficiency associated lung disease. It also focusses on programs comprising hemophilia A and hemophilia B; and research of proprietary programs focused on developing engineered cell therapies to treat various cancers and autoimmune diseases. In addition, the company offers tools comprising of Clustered, Regularly Interspaced Short Palindromic Repeats/CRISPR associated 9 (CRISPR/Cas9) system. It has license and collaboration agreement with Regeneron Pharmaceuticals, Inc. to co-develop potential products for the treatment of hemophilia A and hemophilia B; AvenCell Therapeutics, Inc. to develop allogeneic universal CAR-T cell therapies, and co-develop and co-commercialize allogeneic universal CAR-T cell products for an immuno-oncology indication; SparingVision SAS to develop novel genomic medicines utilizing CRISPR/Cas9 technology for the treatment of ocular diseases; Kyverna Therapeutics, Inc. for the development of an allogeneic CD19 CAR-T cell therapy for the treatment of a variety of B cell-mediated autoimmune diseases; and ONK Therapeutics, Ltd. for the development of engineered NK cell therapies to cure patients with cancer. Intellia Therapeutics, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts. View Source20: In April 2017 Intellia entered into a partnership with Regeneron Pharmaceuticals under which Regeneron gained the exclusive right to use Intellia's CRISPR platform on up to 10 drug targets, of which up to five could be outside of the liver, and the companies agreed to co-develop other targets. Regeneron paid $75 million upfront, as well as milestones and royalties.[18] The company said it planned to put $10 million of the funds into its bioinformatics program, to help it evaluate targets.[19] View Source21: Intellia's proprietary non-viral gene knock out platform deploys lipid nanoparticles to deliver to the liver a two-part genome editing system: guide RNA specific to the disease-causing gene and messenger RNA that encodes the Cas9 enzyme, which carries out the precision editing. Intellia also has a number of research programs for in vivo and ex vivo therapeutic candidates with potential applications in diseases including cancer, alpha-1 antitrypsin deficiency, and hemophilia. The company is also working on a variety of additional gene editing technologies including base editing and DNA writing.[5][6] View Source